A biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material having a sintered CAP core and a closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a homogeneous coarse external surface comprising flat crystal platelets, which shows an enhanced osteogenic response, a method of promoting bone formation, bone regeneration and/or bone repair by implanting the biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material, and a process of preparation thereof.本發明係關於一種展現經增強成骨反應之兩相磷酸鈣/羥基磷灰石(CAP/HAP)骨替代材料，其具有燒結CAP核及封閉的奈米晶HAP磊晶生長層，該磊晶生長層沈積於該燒結CAP核之外表面上，其中沈積於該燒結CAP核之外表面上的該封閉的奈米晶HAP磊晶生長層具有包含扁平晶體薄片之均質粗糙外表面；一種藉由植入該兩相磷酸鈣/羥基磷灰石(CAP/HAP)骨替代材料來促進骨形成、骨再生及/或骨修復之方法；及一種製備其之方法。
