Janine T. Bryan,Michelle K. Brownlow,Li Shi,Danilo Casimiro,William L. McClements,Brian K. Meyer,Binghua Hu
申请号：
US13423847
公开号：
US20120177684A1
申请日:
2012.03.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to pharmaceutical compositions comprising virus-like particles (VLPs) of HPV, said VLPs adsorbed to an aluminum adjuvant, and an ISCOM-type adjuvant comprising a saponin, cholesterol, and a phospholipid. In preferred embodiments, the aluminum adjuvant comprises amorphous aluminum hydroxyphosphate sulfate. Another aspect of the invention provides multi-dose HPV vaccine formulations comprising HPV VLPs and an antimicrobial preservative selected from the group consisting of: m-cresol, phenol and benzyl alcohol. Also provided are methods of using the disclosed pharmaceutical compositions and formulations to induce an immune response against HPV in a human patient and to prevent HPV infection.
