The present invention provides a system and method for supplying, generating, conserving, and managing oxygen that is ideally suited for use on-board an aircraft for supply of breathable oxygen to passengers and flight crew. The system includes several components that together optimize oxygen utilization while reducing costs from maintenance and added weight of traditional pressurized gaseous cylinders. Components of the system include a pressurized cylinder of oxygen enriched gas or a chemical oxygen generator for rapid use in emergency situations, an on-board oxygen generator (OBOG) of the ceramic oxygen generator (COG) type incorporating solid electrolyte oxygen separation (SEOS) technology, a controller, a pulsed oxygen supplier, a crew/passenger breathing mask, and one or more sensors including sensors that detect inhale/exhale phases and communicate with the controller so that flow of oxygen may be regulated for conservation and to adapt to physiological needs.