The General Hospital Corporation;The Broad Institute Inc.;DANA-Farber Cancer Institute, Inc.
发明人:
Nir Hacohen,Catherine Ju-Ying Wu,Edward F. Fritsch
申请号：
US14877125
公开号：
US20160101170A1
申请日:
2015.10.07
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention provides a method of making a personalized neoplasia vaccine for a subject diagnosed as having a neoplasia, which includes identifying a plurality of mutations in the neoplasia, analyzing the plurality of mutations to identify a subset of at least five neo-antigenic mutations predicted to encode neo-antigenic peptides, the neo-antigenic mutations selected from the group consisting of missense mutations, neoORF mutations, and any combination thereof, and producing, based on the identified subset, a personalized neoplasia vaccine.
