Sung Hee PARK,Seung Su KIM,Hyung Kyu LIM,Jae Hyuk CHOI,In Young CHOI,Se Chang KWON
申请号：
US15315992
公开号：
US20170100488A1
申请日:
2015.06.05
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a method for increasing serum half-life of a protein or peptide and decreasing immunogenicity thereof by site-specifically binding a carrier to a protein or peptide, and to the use thereof. The conjugate of the physiologically active protein or peptide of the present invention can significantly decrease immunogenicity in the human body and thus reduce antibody production rate against the protein or peptide. Therefore, the present conjugate has advantages in that a phenomenon of reduced clinical effects of the physiologically active protein or peptide is low, and it can be effectively used in the development of long-acting formulations having a high safety against the immune response.
