ITM Isotopen Technologien München AG;ITM ISOTOPEN TECHNOLOGIEN MUENCHEN AG
发明人:
ZHERNOSEKOV, KONSTANTIN,NIKULA, TUOMO
申请号：
EP11176249.8
公开号：
EP2439747A8
申请日:
2011.08.02
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
Die vorliegende Erfindung betrifft einen 68Ga-Generator, bei welchem dessen 68Ge-Mutternuklid spezifisch an einen Träger über eine Triethoxyphenylgruppe immobilisiert ist und kontinuierlich zu 68Ga zerfällt, wobei die Triethoxyphenylgruppe kovalent über einen Linker an ein Trägermaterial gebunden ist.Generator for gallium-68 daughter nuclide, comprises germanium-68 parent nuclide, which is specifically immobilized on a carrier by trihydroxyphenyl groups or dihydroxyphenyl groups. The parent nuclide immobilized on the carrier is continuously decayed with a half-life of 270.82 days by electron capture, to obtain gallium-68 daughter nuclide. The trihydroxyphenyl groups or the dihydroxyphenyl groups are covalently bonded to the carrier material by a linker comprising esters with 2-20C, alkylene with 2-20C, phenyl thiourea, amines with 2-20C, melamine or trihydroxyphenyl alkoxysilane. Generator for gallium-68 daughter nuclide, comprises germanium-68 parent nuclide, which is specifically immobilized on a carrier by trihydroxyphenyl groups or dihydroxyphenyl groups. The parent nuclide immobilized on the carrier is continuously decayed with a half-life of 270.82 days by electron capture, to obtain gallium-68 daughter nuclide. The trihydroxyphenyl groups or the dihydroxyphenyl groups are covalently bonded to the carrier material by a linker comprising esters with 2-20C, alkylene with 2-20C, phenyl thiourea, amines with 2-20C, melamine or trihydroxyphenyl alkoxysilane, preferably 1,2,3-trihydroxyphenyl triethoxysilane, 1,2,3-trihydroxyphenyl diethoxysilane, 1,2,3-trihydroxyphenyl ethoxysilane, 1,2,3-trihydroxyphenyl tripropoxysilane, 1,2,3-trihydroxyphenyl chlorosilane, epichlorohydrin, isothiocyanates or thiols.
