DETECTING AND TREATING SOLID TUMORS THROUGH SELECTIVE DISRUPTION OF TUMOR VASCULATURE

• 收藏
• 分享

专利权人:

Bert Vogelstein

发明人:

Bert Vogelstein,Yuan Qiao,Xin Huang,Kenneth Kinzler,Shibin Zhou,Luis Diaz

申请号：

US13880608

公开号：

US20130323167A1

申请日:

2011.10.20

申请国别(地区):

US

年份:

2013

代理人:

摘要：

Several agents capable of inducing vascular responses akin to those observed in inflammatory processes enhance the accumulation of nanoparticles in tumors. Exemplary vascular-active agents include a bacterium, a pro-inflammatory cytokine, and microtubule-destabilizing drugs. Such agents can increase the tumor to blood ratio of radioactivity by more than 20-fold compared to nanoparticles alone. Moreover, vascular-active agents dramatically improved the therapeutic effect of nanoparticles containing radioactive isotopes or chemotherapeutic agents.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/