Biomimetic scaffolds are described that incorporate devitalized cells that can function as a depot for the release of cell and tissue supporting factors. Methods for forming the biomimetic scaffolds are also described. The biomimetic scaffolds can be bone tissue biomimetic scaffolds and the devitalized cells of the scaffolds can serve as sustained release depots for osteogenic and bone-forming factors. The biomimetic scaffolds can be particularly beneficial as grafting materials for reconstruction of large (e.g., greater than about 0.5 mm3) skeletal injuries.
