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Novel manufacturing process for triazine, pyrimidine and pyridine derivatives
专利权人:
Piqur Therapeutics AG;Universitaet Basel
发明人:
Hebeisen, Paul,Beaufils, Florent,Langlois, Jean-Baptiste
申请号:
AU2015250994
公开号:
AU2015250994A1
申请日:
2015.04.20
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
The invention relates to a method of manufacturing triazine, pyrimidine and pyridine derivatives of formula (I), wherein U, V, W and Z are nitrogen or carbon atoms, whereby at least one of U, V and W is nitrogen, and the other substituents are defined as in the specification, by condensing a corresponding halo-triazine, pyrimidine or pyridine in a type of Suzuki coupling with a pyridyl- or pyrimidinyl-borane, wherein the amino function is protected as a formamidine. The invention further relates to suitable intermediates and methods of manufacturing of such intermediates. Furthermore the invention relates to pure 5-(4,6-dimorpholino-1,3,5- triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine in solid form.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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