Katherine F. Terranova;Roger A. Rajewski;Bala Subramaniam;Jeffrey M. Jonas
发明人:
Jeffrey M. Jonas,Roger A. Rajewski,Bala Subramaniam,Katherine F. Terranova
申请号：
US12394833
公开号：
US08221779B2
申请日:
2009.02.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present embodiment of the invention is generally directed to compositions comprising suspensions of poorly water-soluble compounds recrystallized in nanoparticulate sizes ranging from 0.1 to 5 μm. In addition, the embodiment of the invention is directed to methods for preparation and administration of these compositions to a patient for prevention and treatment of disease states. In particular, the embodiment of the invention is directed to compositions comprising suspensions of poorly water-soluble compounds, such as antimitotics and antibiotics, in nanoparticulates and methods of prevention and treatment of chronic disease states, such as cancer, by intraperitoneal and intravenous administration of such compositions.
