SAPREME TECHNOLOGIES B.V.;CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN
发明人:
POSTEL, Ruben,FUCHS, Hendrik
申请号：
EPEP2019/084211
公开号：
WO2020/126610A1
申请日:
2019.12.09
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The current invention relates to an effector moiety capable of inducing an intracellular effect when present inside a mammalian cell, the effector moiety comprising a payload conjugated with at least one saponin. The invention also relates to an antibody-drug conjugate comprising the effector moiety according to the invention, or a ligand-drug conjugate comprising the effector moiety of the invention, the effector moiety comprising covalently coupled saponin. The invention also relates to a therapeutic combination comprising: (a) the effector moiety of the invention, comprising at least one saponin, and optionally a pharmaceutically acceptable excipient； and (b) an antibody-drug conjugate or a ligand-drug conjugate, and optionally a pharmaceutically acceptable excipient. Further, the invention relates to a pharmaceutical composition comprising the effector moiety of the invention or the antibody-drug conjugate of the invention or the ligand-drug conjugate of the invention, comprising at least one saponin covalently linked to the effector molecule, and optionally a pharmaceutically acceptable excipient. The invention also relates to the effector moiety of the invention or the antibody-drug conjugate of the invention or the therapeutic combination of the invention or the ligand-drug conjugate of the invention or the pharmaceutical composition of the invention, for use as a medicament. Finally, the invention also relates to the effector moiety of the invention or the antibody-drug conjugate of the invention or the therapeutic combination of the invention or the ligand-drug conjugate of the invention or the pharmaceutical composition of the invention, for use in the treatment or prevention of a cancer or an autoimmune disease.La présente invention concerne une fraction effectrice capable d'induire un effet intracellulaire lorsqu'elle est présente à l'intérieur d'une cellule de mammifère, la fraction effectrice comprenant une charge utile conjuguée à au moins une saponin
