Disclosed is a portable, wearable device for measuring parameters including blood oxygenation, galvanic skin response, skin temperature, pulse rate, blood pressure, and exertion level, and diagnosing stress and other conditions which cause stress-like physiological responses based on the results of the monitoring and on patient input of feelings and symptoms. Specific queries and advice on stress reduction, related disease management, and stress and disease education is also provided to the patient through the device.