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ANTIBODIES THAT BIND OV064 AND METHODS OF USE THEREFOR
专利权人:
Ole Petter Veiby
发明人:
Ole Petter Veiby,John S. Babcook
申请号:
US14249299
公开号:
US20140328751A1
申请日:
2014.04.09
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Antibodies and antigen-binding fragments of antibodies that bind OV064 are disclosed. The antibodies bind an extracellular domain of OV064. Some of the antibodies and antigen-binding fragments bind an epitope on OV064 sufficient to induce internalization. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.
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