A knee brace for use by athletes or others requiring protection and support of the knee. The knee brace protects against abnormal motions of the knee, and provides direct and indirect patella stabilization. A base comprised of elastic material is configured to closely fit around portions of the knee and adjacent leg portions. Direct patella support is provided by upper crossed straps that are permanently fastened to the base and cross the front of the leg above the knee, or by lower crossed straps that are permanently fastened to the base and cross the front of the leg below the knee, or by both upper and lower crossed straps. Additional direct patella support may be provided by a patella opening. One or more generally upright lateral pockets containing semi-rigid stays may also be provided on the sides of the base for lateral support. A popliteal opening may be provided to reduce the possibility of chafing at the rear of the knee.