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Bi-dentate compounds as kinase inhibitors
专利权人:
Maurizio Pellecchia
发明人:
Maurizio Pellecchia
申请号:
US12970813
公开号:
US08431529B2
申请日:
2010.12.16
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present disclosure provides compound having the general structure A or pharmaceutically acceptable salts thereof:Het-L-P  (A)wherein Het is an aromatic moiety comprising a heterocyclic structure mimicking ATP, P is a docking site derived peptide or a docking site peptide mimetic, and L is a linking moiety, wherein L links the ATP mimetic to the docking site peptide moiety. The compounds having the general structure A can serve as inhibitors of kinases, such as the kinases JNK, Erk and p38.
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