Maxim Sergeev,Federica Morgia,Robert Michael Van Dam,Mark Lazari
申请号：
US15323046
公开号：
US09895454B2
申请日:
2015.07.02
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Inter alia, the first titania-catalyzed [18F]-radiofluorination in highly aqueous medium is provided. In embodiments, the method utilizes titanium dioxide, 1:1 acetonitrile-thexyl alcohol solvent mixture and tetrabutylammonium bicarbonate as a base. Radiolabeling may be directly performed with aqueous [18F]fluoride without the need for drying/azeotroping step, which reduces radiosynthesis time while keeping high fluoride conversion. The general applicability of the synthetic strategy to the synthesis of the wide range of PET probes from tosylated precursors is demonstrated.
