Antonin de Fougerolles,Atanu Roy,Jason P. Schrum,Suhaib Siddiqi,Paul Hatala,Stephane Bancel
申请号：
US13644072
公开号：
US09428535B2
申请日:
2012.10.03
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure provides methods of increasing the level of a polypeptide of interest in a mammalian subject by administering a polynucleotide having one or more chemical modifications and a Protein:Cytokine ratio of greater than 100.
