The present invention belongs to the field of Chinese herbal medicine products, and more particularly relates to a formulation, preparation method and use of a Chinese herbal medicine composition for soothing the liver. The present invention provides a Chinese herbal medicine composition for soothing the liver, wherein the raw materials of the composition comprise Rhizoma Cyperi, Radix Angelicae Sinensis, Rhizoma Ligustici Chuanxiong, Radix Paeoniae Alba, and Pericarpium Citri Reticulatae. The present invention further provides a preparation method of the composition, comprising: step 1, extracting; step 2, concentrating; and Step 3, drying. Moreover, the present invention provides the use of the composition and the product obtained by the method in the treatment of a breast disease and/or remission of depression.