The present invention relates to a method of preparing an intranasal composition including from about 0.0010-0.0040% by weight capsaicin, from about 0.50-0.90% by weight hydroxypropyl methylcellulose, from about 0.010-0.080% by weight n-alkyl dimethyl benzyl ammonium chloride (Quat), and various moisturizing and irrigation agents, wherein the method includes dissolving the above components in water to form an aqueous solution and filtering the aqueous solution to form an intranasal composition. The present invention further relates to an intranasal drug delivery composition, which includes from about 0.0010-0.0040% by weight capsaicin, from about 0.50-0.90% by weight hydroxypropyl methylcellulose, from about 0.010-0.080% by weight n-alkyl dimethyl benzyl ammonium chloride (Quat), and various moisturizing and irrigation agents. The present invention further relates to a method to increase tolerability and reduce burning from capsaicin when applied to nasal mucosa in the form of an intranasal composition, which includes combining capsaicin with the materials as noted above.
