Kwang Meyung KIM,Sun Hwa KIM,Ick Chan KWON,Ji Young YHEE,Sojin LEE
申请号：
US14340845
公开号：
US20150038690A1
申请日:
2014.07.25
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed is a gelatin-based nanoparticle complex for tumor-targeted delivery of siRNA for specific gene silencing in tumor cells. The gelatin-based nanoparticle complex includes: poly-siRNA chains whose ends are modified with thiol groups and thiolated gelatin bound to the poly-siRNA chains through disulfide crosslinking and charge interactions. The gelatin-based nanoparticle complex is not degraded in the bloodstream and can be efficiently absorbed into tumor cells without cytotoxicity. The delivered siRNA can effectively silence target gene expression. Also disclosed is a method for preparing the gelatin-based nanoparticle complex.
