Peter Astrup Christensen;Søren Kragh Moestrup;Niels Jonas Heilskov Graversen;Pia Svendsen;Gabriele Anton;Holger Jon Møller
发明人:
Niels Jonas Heilskov Graversen,Pia Svendsen,Peter Astrup Christensen,Søren Kragh Moestrup,Holger Jon Møller,Gabriele Anton
申请号:
US13498511
公开号:
US20120276193A1
申请日:
2010.09.29
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to therapeutic agents for the targeted delivery of an immunosuppressive agent to monocytes and/or monocyte-derived cells comprising a binding moiety with specificity for monocytes and/or monocyte-derived cells and an immunosuppressive agent. In one embodiment, the agent is a glucocorticoid-antibody conjugate. The invention also relates to methods, uses, kits and compositions comprising such agents.