Patent No. 597452 Disclosed is an isolated plasminogen variant, plasmin variant, or plasmin derivative, or a combination of any thereof for use as a medicament, wherein the isolated plasminogen variant or plasmin obtained from it, or an isolated plasmin variant, or a proteolytically active or reversible inactive derivative of any of said plasmins comprises in its catalytic domain the mutation of at least one internal amino acid at position P of which the peptide bond with internal amino acid at position P+1 is prone to autoproteolysis into an amino acid of which the peptide bond with internal amino acid at position P+1 is less prone to autoproteolysis, and wherein the autolysis constant of the variant plasmin is at most 95% of the autolysis constant of wildtype plasmin.
