The inventive valve prosthesis (10) comprises a flexible plug (54) and an annular bearing reinforcement (12) which is embodied such that it is radially rigid and surgically implantable in the area of a heart valve. Said valve prosthesis is provided with an interchangeable prosthetic valve (50), is independent of the bearing reinforcement (12), endoluminally placeable and comprises a tubular support (52) which is radially deformable between a folded setting position and an unfolded position for implanting into a bearing structure and said flexible plug (54) connected to a tubular support (52). The bearing reinforcement (12) forms an annular support devoid of any plug capable to univocally limit a blood flow circulation.
