Avi TOVI,Chaim EIDELMAN,Shimon SHUSHAN,Alon HAGI,Alexander IVCHENKO,Gabriel-Marcus BUTILCA,Leah BAR-OZ,Tehila GADI,Gil ZAOVI
申请号：
US13850137
公开号：
US20130196917A1
申请日:
2013.03.25
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp9-Bivalirudin] and each is impurity less than 1.0%, and preferably having a purity of at least about 99.0% by HPLC, wherein the total impurities amount to less than 1.0%, comprising not more than 0.5% [Asp9-Bivalirudin] and each impurity is less than 0.5%.
