Johannes Bartholomäus,Heinrich Kugelmann,Elisabeth Arkenau-Maric
申请号：
US15878524
公开号：
US20180147149A1
申请日:
2018.01.24
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
