Sartaj Tabassum,Hamad A. Al-Lohedan,Hazem Ghabour,Mohd Sajid Ali,Rais Ahmad Khan,Fohad Mabood Husain
申请号：
US15730637
公开号：
US10053480B1
申请日:
2017.10.11
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The anti-quorum and DNA cleaving agent is directed to a ruthenium complex formulated from dichloro-(η6-p-cymene) ruthenium(II) dimer and 2-chloroquinoxaline, the complex having the formula:The reaction cleaves the dimer, leaving a half-sandwich ruthenium complex with an η6 coordination bond to the arene ligand and an Ru—N bond attaching the chloroquinoxaline to the ruthenium complex. The agent has an anti-quorum sensing effect on bacteria, inhibiting the formation of biofilm and inhibiting bacterial virulence. The agent also binds to DNA and may cleave the DNA, e.g., at the N7 base pair of guanine, due to a hydrolytic mechanism, suggesting potential use as an anticancer or antitumor agent.
