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compound, composition, kit, and, use of a compound
- 专利权人:
- ASANA BIOSCIENCES; LLC
- 发明人:
- Hosahalli Subramanya,Prabhakara Rao Nadipalli,ROGER A. SMITH,SAUMITRA SENGUPTA,SCOTT K. THOMPSON,Sanjeeva Reddy,Sunil Kumar Panigrahi,Tyler M. John,VIJAY POTLURI,Vijay Kumar Nyavanandi
- 申请号：
- BR112015025901
- 公开号：
- BR112015025901A8
- 申请日:
- 2014.04.11
- 申请国别(地区):
- BR
- 年份:
- 2020
- 代理人:
- 摘要：
- 1/ 1 summary: Composite, composite, kit, and, all to co-regulate/raf/mek/erk and pi3k/akt/pten/mtor, to treat a condition and a disease and to monitor the effectiveness of a composite from this application, new kinazolin and azakinzolin and chemically acceptable salts thereof. They are also provided for allPrepare these compounds. These compounds are agile to track the paths o f ras/raf/mek/erk and pi3k/akt/pten/mtor by administering a therapeutically effective quantity of one or more of the 4-8(i)on that x, y, t and r,And r r r a r e defined here, to a patient. In doing so, these compounds are effective in treating conditions associated with disruption of the routes of ras/raf/mek/erk and pi3k/akt/pten/mtor. a variety of conditions can be treated using these compounds and includes diseases that are characterized by abnormal cell proliferation. In a modality, illness is. (i)1 / 1 resumo “composto, composiã‡ãƒo, kit, e, mã‰todos para corregular ras/raf/mek/erk e pi3k/akt/pten/mtor, para tratar uma condiã‡ãƒo e uma doenã‡a e para monitorar a eficã�cia de um composto â€� o presente pedido prov㪠novas quinazolinas e azaquinazolinas e sais farmaceuticamente aceitã¡veis das mesmas. tambã©m sã£o providos mã©todos para preparar estes compostos. estes compostos sã£o ãºteis para corregular caminhos de ras/raf/mek/erk e pi3k/akt/pten/mtor por administraã§ã£o de uma quantidade terapeuticamente eficaz de um ou mais dos 4 6 8' compostos da fã³rmula (i), em que x, y, t e r , e r a r sã£o aqui definidos, a um paciente. fazendo isto, estes compostos sã£o eficazes no tratamento de condiã§ãµes associadas ã desregulaã§ã£o dos caminhos de ras/raf/mek/erk e pi3k/akt/pten/mtor. uma variedade de condiã§ãµes pode ser tratada usando estes compostos e inclui doenã§as que sã£o caracterizadas por proliferaã§ã£o celular anormal. em uma modalidade, a doenã§a ã© cã¢ncer. (i)
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
