AXEL HARRENGA,SIMONE GREVEN,ANDREAS WILMEN,CHRISTIANE OTTO,SIEGMUND WOLF,CHRISTOPH FREIBERG,MARK TRAUTWEIN,SANDRA BRUDER,ANDREA EICKER
申请号：
PT10776753
公开号：
PT2510002T
申请日:
2010.11.18
申请国别(地区):
PT
年份:
2016
代理人:
摘要：
The present invention is directed to neutralizing prolactin receptor antibodies and antigen binding fragments, pharmaceutical compositions containing them and their use in the treatment or prevention of benign disorders and indications mediated by the prolactin receptor such as endometriosis, adenomyosis, non-hormonal female contraception, benign breast disease and mastalgia, lactation inhibition, benign prostate hyperplasia, fibroids, hyper- and normoprolactinemic hair loss, and cotreatment in combined hormone therapy to inhibit mammary epithelial cell proliferation. The antibodies of the invention block prolactin receptor-mediated signaling.
