A method of compensating ultrasound image comprising demarcating a plurality of a main material regions of an ultrasound image executing a full compensation process to generate a full compensation image according to a first attenuation curve of the main material region generating a brightness comparison table including a plurality of brightness zones which are correspond to a plurality of brightness compensation values according to a plurality of first pixel brightness values of the ultrasound image and a plurality of second pixel brightness values of the full compensation image executing a linear sum process to generate a compensation image including a second attenuation curve according to the brightness compensation values generating a compensation curve according to the first and second attenuation curve executing space comparison process to the compensation image to generate a better compensation image according to the compensation curve.