A pill crusher comprises a base, a U-shaped movable crushing member, a first connecting rod, a handle, and a stopper. The U-shaped movable crushing member, the first connecting rod, the handle, and the stopper form a deformable four-connecting-rod structure. The U-shaped movable crushing member and the stopper form a V-shaped crushing cavity. As the handle is pressed downward, a space of the V-shaped crushing cavity is gradually closed. As the handle is lifted upward, the space of the V-shaped crushing cavity is gradually opened. The U-shaped movable crushing member can rub with respect to the stopper. The pill crusher pulverizes a pill in a highly efficient way, greatly buffers a reaction force in crushing a pill, reduces burden of users, and reduces potential wrist and elbow damage of medical staff caused by long term use.