Peter Stephen Conti;Wentao Zhu;Richard M. Leahy;Bing Bai;Quanzheng Li
发明人:
Richard M. Leahy,Wentao Zhu,Quanzheng Li,Bing Bai,Peter Stephen Conti
申请号：
US14739929
公开号：
US10022097B2
申请日:
2015.06.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A medical imaging system for reconstructing quantitative dynamic nuclear medicine images of a subject may include a three dimensional positron emission tomography (3D PET) scanner and a data processing system. The three dimensional positron emission tomography (3D PET) scanner may: perform scans of the subject at each of multiple bed positions, each scan being of only a sub-portion of the subject that is within an axial length covered by the scanner； and generate dynamic list-mode PET data that: represents a total number of photon pairs arriving at each of multiple detector pairs in the 3D PET scanner； and is organized in a list of elements, each element in the list including a detector pair index and an arrival time for each detected photon pair； and acquires PET data using a dynamic PET protocol with at least two scans at each of the multiple bed positions. The data processing system may: reconstruct Patlak slope and intercept images of the subject over an axial length of the subject that exceeds the axial length of each scan of the subject by optimizing a likelihood or penalized likelihood function using the list-mode PET data from at least two scans of the subject at each of the multiple bed positions； and store the reconstructed image in a storage device or displays the reconstructed image on a display system.
