HAI, TON THAT,GREEN, JOHN-BRUCE DEVAULT,FULGHUM, TIMOTHY MICHAEL,MESSERSMITH, PHILLIP BYRON,SILEIKA, TADAS STANISLOVAS
申请号：
CA2906621
公开号：
CA2906621A1
申请日:
2014.03.14
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.
