There are provided thieno[2,3-c]pyrazole derivatives of formula (I), wherein A is an aryl or heteroaryl ring, on which the substituent-NHZR5 is at the ortho position to the CONH linker； R1 and R2 are the same or different and, independently from each other, represent a hydrogen atom or an organic group； R4 is a hydrogen or halogen atom or an organic group； Z is direct bond, >；C&boxH；O, or &mdash；C(&boxH；O)NH&mdash；； R5 is hydrogen or an organic group； or isomers, tautomers, carriers, metabolites, prodrugs, and pharamaceutically acceptable salts thereof. A process for their preparation and pharamaceutical compositions comprising them are also disclosed； the compounds of the invention may be useful, in theraphy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
