A method of promoting tissue adhesion to reinforce tissue apposition that may include collecting a first tissue portion, collecting a second tissue portion, placing one or more tissue securement devices through the first and second tissue portions, tightening the one or more tissue securement devices to approximate the first and second tissue portions, and placing a fixation agent between the first and second tissue portions. The method promotes tissue adhesion between one or more portions of tissue, wherein the tissue adhesion may reinforce a tissue apposition.