Brian L. HODOUS;Stephanie D. Geuns-Meyer;Philip R. Olivieri;Vinod F. Patel;Paul A. Tempest
发明人:
Brian L. HODOUS,Stephanie D. Geuns-Meyer,Philip R. Olivieri,Vinod F. Patel,Paul A. Tempest
申请号：
US13490337
公开号：
US20120245206A1
申请日:
2012.06.06
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to compounds of Formulas I and II,wherein B1, B2, B3, B4, C1, C2, ring D, L1, L2 and R1-4 are defined herein, synthetic intermediates, and pharmaceutical compositions, comprising such compounds. The compounds and compositions are capable of modulating various protein kinase receptors such as Tie-2 and Aurora and, therefore, influencing kinase related disease states and conditions. The compounds, for example, are capable of treating cancer caused by unregulated angiogenesis, and inflammation as well as other proliferative disorders.
