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STROKE TREATMENT USING ISOLATED PLACENTARY CELLS
专利权人:
АНТРОДЖЕНЕЗИС КОРПОРЕЙШН (US)
发明人:
ЗЕЙТЛИН Энди (US),ПАЛ Аджай (US)
申请号:
RU2011110390/15
公开号:
RU2011110390A
申请日:
2009.08.20
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A method of treating an individual having a blood flow disorder in or around the brain, comprising administering to said individual an effective amount of isolated human adhesive placental cells, which are:! CD10 +, CD34-, and CD105 +; ! CD200 + and HLA-G +; ! CD73 +, CD105 +, and CD200 +; ! CD200 + and OCT-4 +; ! CD73 +, CD105 + and HLA-G +; ! CD73 + and CD105 +, and contribute to the formation of one or more embryoid-like bodies in a population of placental cells containing said stem cells when said population is cultured under conditions that allow the formation of an embryoid-like body; or ! OCT-4 + and contribute to the formation of one or more embryoid-like bodies in a placental cell population containing stem cells when the population is cultured under conditions that allow the formation of embryoid-like bodies; or any combination thereof. ! 2. The method of claim 1, wherein said CD10 +, CD34-, CD105 + cells are further CD200 +. ! 3. The method of claim 2, wherein said CD10 +, CD34-, CD105 +, CD200 + cells are further CD45- or CD90 +. ! 4. The method of claim 3, wherein said CD10 +, CD34-, CD105 +, CD200 + cells are further CD45- and CD90 +. ! 5. The method according to claim 1, wherein said therapeutically effective amount is the number of said cells, which leads to the elimination, detectable improvement, decrease in severity or slowdown of the development of one or more symptoms of blood flow disorders in or around the brain manifested by said individual. ! 6. The method of claim 5, wherein said symptom is hemiplegia or hemiparesis. ! 7. The method of claim 5, wherein said symptom is facial muscle weakness.1. Способ лечения индивидуума, имеющего нарушение кровотока в мозге или вокруг него, включающий введение указанному индивидууму эффективного количества изолированных человеческих адгезивных плацентарных клеток, которые представляют собой: !CD10+, CD34-, и CD105+; ! CD200+ и HLA-G+; ! CD73+, CD105+, и CD200+; ! CD200+ и OCT-4+; ! CD73+, CD105+ и HL
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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