The present invention is a novel compound 9-deoxo-31- O- demethyl-prolyl-FK506, 9-deoxo-36,37-dihydro-FK506, 31- which can be used as a main component of a pharmaceutical composition for the prevention or treatment of neurological diseases O -demethyl-36,37-dihydro-FK506, 9-deoxo-31- O -demethyl-36,37-dihydro-FK506, 9-deoxo-FK520, 31- O -demethyl-FK520, 9-deoxo-31- O -demethyl-FK520, 9-deoxo-FK523, or 9-deoxo-31- O- demethyl-FK523 relates to the manufacture and prevention or treatment of neurological diseases thereof.본 발명은 신경계 질환의 예방 또는 치료용 약학적 조성물의 주요 성분으로 활용이 가능한 신규 화합물 9-deoxo-31-O-demethyl-prolyl-FK506, 9-deoxo-36,37-dihydro-FK506, 31-O-demethyl-36,37-dihydro-FK506, 9-deoxo-31-O-demethyl-36,37-dihydro-FK506, 9-deoxo-FK520, 31-O-demethyl-FK520, 9-deoxo-31-O-demethyl-FK520, 9-deoxo-FK523, 또는 9-deoxo-31-O-demethyl-FK523의 제조 및 이의 신경계 질환의 예방 또는 치료용도에 관한 것이다.
