This application provides by the way that metered dose inhaler is transpulmonary or the composition of nasal delivery there two or more activating agents, method and system. In one embodiment, the composition includes suspension media, active agent particle and suspended particulate, and wherein active agent particle and suspended particulate form suspension altogether in suspension media.本申請提供了通過定量吸入器經肺或經鼻遞送兩種或多種活性劑的組合物、方法及系統。在一個實施例中,該組合物包含懸浮介質、活性劑顆粒及懸浮顆粒,其中活性劑顆粒及懸浮顆粒在懸浮介質中形成共懸浮液。