SEAL, JONATHAN,STEMP, GEOFFREY,THOMPSON, MERVYN,WESTAWAY, SUSAN
申请号：
ES07765418
公开号：
ES2379658T3
申请日:
2007.06.14
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula (I) or its salts: wherein A is phenyl or a 6-membered heteroaryl ring, optionally substituted with halogen, C (1-4) alkyl or C (1-4) alkoxy； R1 and R2 are independently H or C (1-4) alkyl； R3 is optionally substituted phenyl or 5- or 6-membered heteroaryl, optionally substituted； When R3 is substituted, it may have 1, 2, 6 or 3 substituents, each independently selected from halogen, C (14) alkyl, C (1-4) alkoxy, C (3-7) cycloalkyl, hydroxy, trifluoromethoxy, trifluoromethyl, nitro , cyano, phenyl, NH2, NHR5, NR5R6, NHC0R5, NHS02R5, C (0) CF3, C (0) C (1-4) alkyl, C (0) C (3-7) cycloalkyl, C (0) 0Calkyl (1-4), C (0) 0 C (3-7) cycloalkyl, 0C (0) C (1-4) alkyl, 0C (0) C (3-7) cycloalkyl, C0NH2, C0NHR5, C0NR5R6, S0R6, S02CF3 , S02R6, 0S02R6, 0S02CF3, S02NH2, S02NHR5, S02NR5R6, where R5 and R6 can be the same or different and represent C (14) alkyl, halogen-substituted phenyl or 5 or 6-membered optionally substituted with halogen； Y is NH, 0, CH2 or a bond； and R4 is C (1-4) alkyl or C (1-4) alkoxy C (1-4) alkyl.Un compuesto de fórmula (I) o sus sales: en donde A es fenilo o un anillo heteroarilo de 6 miembros, opcionalmente sustituido con halógeno, alquilo C (1-4) o alcoxi C (1-4)； R1 y R2 son independientemente H o alquilo C (1-4)； R3 es fenilo opcionalmente sustituido o heteroarilo de 5 o 6 miembros, opcionalmente sustituido； Cuando R3 se sustituye, puede tener 1, 2 6 3 sustituyentes, cada uno seleccionados independientemente de halógeno, alquilo C (14), alcoxi C (1-4), cicloalquilo C (3-7), hidroxi, trifluorometoxi, trifluorometilo, nitro, ciano, fenilo, NH2, NHR5, NR5R6, NHC0R5, NHS02R5, C (0) CF3, C (0) alquilo C (1-4), C (0) cicloalquilo C (3-7), C (0) 0alquiloC (1-4), C (0) 0cicloalquilo C (3-7), 0C (0) alquiloC (1-4), 0C (0) cicloalquilo C (3-7), C0NH2, C0NHR5, C0NR5R6, S0R6, S02CF3, S02R6, 0S02R6, 0S02CF3, S02NH2, S02NHR5, S02NR5R6, donde R5 y R6 pueden ser iguales o diferentes y representan alquilo C (14), fenilo opcionalmente sustituido
