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COMPOSÉ PHARMACEUTIQUE
专利权人:
Iomet Pharma Ltd.
发明人:
申请号:
EP15753924.8
公开号:
EP3182972A1
申请日:
2015.08.13
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises the following formula (I): wherein X1 is selected from C and N; X3 and X5 may be the same or different and each is independently selected from C, N, O and S; Y is selected from N and O; Z is selected from C, N and O; each bond represented by a dotted line may independently be a double bond or a single bond, provided that valencies at each ring atom are maintained and provided that the ring Q contains at least one double bond and provided that the atom N has a double bond; R3 and R5 may be present or absent and may be the same or different and each is independently selected from H and a substituted or unsubstituted organic group, provided that the number of R3 groups present is such that the valency of X3 is maintained, and the number of R5 groups present is such that the valency of X5 is maintained; each R11 and R12 may be present or absent and may be the same or different and each is independently selected from H and a substituted or unsubstituted organic group, provided that the number of R11 and R12 groups present is such that the valency of Z is maintained; R21 is selected from H and a substituted or unsubstituted organic group; R22 may be present or absent and is selected from H and a substituted or unsubstituted organic group; and Cy is a cyclic organic group.L'invention concerne un composé inhibiteur tryptophane-2,3-dioxygénase (TDO) et/ou indoleamine-2,3-dioxygénase (IDO) utilisé dans un médicament, ledit composé étant de formule (I) : X1 est choisi parmi C et N ; X3 et X5 peuvent être identiques ou différents et chacun est indépendamment choisi parmi C, N, O et S ; Y est choisi parmi N et O ; Z est choisi parmi C, N et O ; chaque liaison représentée par une ligne en pointillé peut être indépendamment une liaison double ou une liaison simple, à condition que les valences pour chaque atome de cycle soient mai
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
cowley, philip
wise, alan

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