Polymorphic forms of a 3-pyrrole substituted 2-indolinone

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专利权人:

Stephen Benedict David Winter

发明人:

Stephen Benedict David Winter,Bernardino Mangion

申请号：

US12747762

公开号：

US08389562B2

申请日:

2008.12.12

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The invention relates to new crystalline polymorphic forms of N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (i.e., sunitinib base), including Form I, Form II, and Form IV, processes for preparing crystalline polymorphic forms of sunitinib base, and pharmaceutically acceptable salts of new crystalline polymorphic forms of sunitinib base and pharmaceutical compositions comprising new crystalline polymorphic forms of sunitinib base, salts of new crystalline polymorphic forms of sunitinib base and mixtures thereof.

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