The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson’s disease, Alzheimer’s disease and amyotrophic lateral sclerosis (ALS).本發明關於抑制LRRK2激酶活性的新穎化合物、其製備方法、含其之組成物以及關於及其在治療或預防與LRRK2激酶活性相關或以LRRK2激酶活性為特徵之疾病中的用途,例如帕金森病、阿爾茨海默病及肌萎縮側索硬化症(ALS)。