David Shanahan,John Nemunaitis,Neil Senzer,Phillip Maples,Donald Rao
申请号：
US11601431
公开号：
US08603991B2
申请日:
2006.11.17
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Methods for treating cancer that include (a) obtaining a specimen of cancer issue from a patient (b) obtaining a specimen of normal tissue in the proximity of the cancer tissue (c) extracting total protein from the cancer tissue and normal tissue (d) obtaining a protein expression profile of the cancer tissue and normal tissue (e) identifying a group of proteins that are expressed in the cancer tissue at significantly different levels than in the normal tissue (f) identifying one or more prioritized proteins from the group of proteins, which will serve as the target for an RNA interference molecule (RNAi), which, when provided to a patient, will reduce the expression level of the one or more prioritized proteins using both cleavage-dependent and cleavage-independent pathways of the RNA-induced silencing complex (RISC).
