Novel FXR (NR1H4) binding and activity modulating compounds

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专利权人:

Phenex Pharmaceuticals AG

发明人:

KINZEL, Olaf,STEENECK, Christoph,KREMOSER, Claus

申请号：

AU2016265993

公开号：

AU2016265993A1

申请日:

2016.11.29

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

#$%^&*AU2016265993A120161215.pdf#####Abstract The present invention relates to compounds which bind to the NRiH4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of disease and/or conditions througli binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds (1). Z is selected from (a), (b), (c) or (d). OH 0 z Ri, ,N, R-1 NN RI O RI N RN N RN R2 R2 R2-( R2 ( ( ) (2 R2~ 2 VZ-X aX (b) .:ZX (c4 (d)

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http://www.ckcest.cn/home/