A cooled microwave denervation catheter includes a catheter body having at least one fluid passage and an interior lumen therein, a balloon in communication with the at least one fluid passage to receive cooling fluid to inflate the balloon, and a microwave antenna catheter configured to be inserted into the interior lumen of the catheter body. The microwave antenna catheter has a distal end configured to engage a taper of the interior lumen, thereby positioning the microwave antenna in a desired location of the interior lumen.