BORTHWICK, ALAN DAVID,MILLS, MARK TREVOR,BROWN, JANE THERESA,CORCORAN, JONATHAN PATRICK THOMAS,DE CASTRO VASCONCELOS GONCALVES, MARIA BEATRIZ,KALINDJIAN, SARKIS BARRET
申请号：
CA2970574
公开号：
CA2970574A1
申请日:
2015.12.16
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain bicycloheteroaryl-heteroaryl-benzoic acid compounds of the following formula (for convenience, collectively referred to herein as "BHBA compounds"), which, inter alia, are (selective) retinoic acid receptor beta (RARß) (e.g., RARß2) agonists. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to (selectively) activate RARß (e.g., RARß2), to cause or promote neurite development, neurite outgrowth, and/or neurite regeneration, and in the treatment of diseases and conditions that are mediated by RARß (e.g., RARß2), that are ameliorated by the activation of RARß (e.g., RARß2), etc., including, e.g., neurological injuries such as spinal cord injuries.
