A restraining device for covering and protecting an intravenous access site or other access site that comprises an intravenous compartment hub portion or tubing device hub portion, coupled to a U-shaped portion coupled to a straight tubing portion. The combination of the compartment hub portion, U-shaped portion and straight tubing portion allows for an area where the intravenous catheter, catheter needle, luer lock and tubing can be placed, surrounding which is a flat, generally planar area that includes an adhesive backing for adhering the device to the skin of a patient. The anchoring protection device is a one-piece unit that is made from a thin, transparent, flexible material.