Mary STRUTHERS,Jonathan Harry Davis,Michael Louis Doyle,Priyanka Apurva Madia
申请号：
US16435420
公开号：
US20190359672A1
申请日:
2019.06.07
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Disclosed herein are fusion proteins comprising: (a) a first polypeptide comprising Interleukin-2 (IL2)； and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL2Rα), wherein IL2 or IL2Rα comprises at least one fewer glycosylation site compared to native IL2 or native IL2Rα. Methods of production and methods of therapeutic use of the fusion proteins are also disclosed.
