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TRANSDERMAL THERAPEUTIC SYSTEM FOR 5-AMINOLEVULINIC ACID HYDROCHLORIDE
专利权人:
ЛТС ЛОМАНН ТЕРАПИ-СИСТЕМЕ АГ (DE)
发明人:
ЮНГ Тобиас (DE),ХОРСТМАНН Михаэль (DE),ХОФФМАНН Герд (DE)
申请号:
RU2014111255/15
公开号:
RU2014111255A
申请日:
2012.08.24
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A transdermal therapeutic system, comprising a back layer impervious to the active substance, a polymer matrix containing the active substance and a detachable protective layer, characterized in that the active substance is 5-aminolevulinic acid hydrochloride, and the base polymer of the polymer matrix is an adherent polyacrylate. 2. Transdermal therapeutic system according to claim 1, characterized in that it is a monolithic system of the type "active substance in the adhesive." 3. The transdermal therapeutic system according to claim 1, characterized in that the 5-aminolevulinic acid hydrochloride is crystalline 5-aminolevulinic acid hydrochloride. The transdermal therapeutic system according to claim 3, characterized in that the size of 50% crystals of crystalline 5-aminolevulinic acid hydrochloride exceeds the thickness of the layer of the polymer matrix. The transdermal therapeutic system according to claim 3, characterized in that more than 99.9% of the crystals of crystalline 5-aminolevulinic acid hydrochloride are smaller than about 250 microns and particularly preferably have a particle size of from 90 to 160 microns. Transdermal therapeutic system according to claim 1, characterized in that the polymer matrix contains less than 30 wt. -%, preferably less than 20% of the mass. and particularly preferably less than 5% of the mass. plasticizer in terms of polyacrylate. 7. The transdermal therapeutic system according to claim 1, characterized in that the polyacrylate is obtained without a crosslinking agent. The transdermal therapeutic system according to claim 1, characterized in that the polyacrylate contains acid functional groups. Transdermal therapeutic system according to claim 1, ex.1. Трансдермальная терапевтическая система, включающая непроницаемый для действующего вещества тыльный слой, содержащую действующее вещество полимерную матрицу и отделяющийся защитный слой, отличающаяся тем, что действующим веществом является гидрохлорид 5-аминолевулиново
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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