The invention relates to hydroxyethyl sulfonate of cyclin dependent protein kinase inhibitor, its crystal form and preparation method.Specifically, the invention relates to 6-acetyl-8-cyclopentyl-5-methyl-2-yl (5-piperidine-4-yl) pyridine-2-yl) amino pyridine and [2,3-d] pyrimidine-7 (8h) ketone hydroxyethyl sulfonate (formula (I)) compound, the type I crystallization and the preparation method thereof.The type I crystal of the compound of formula (I) has good chemical stability and crystal stability, and the crystal solvent used is low toxicity and low residue, which can be better used in clinical treatment.本發明涉及一種周期素依賴性蛋白激酶抑制劑的羥乙基磺酸鹽、其結晶形式及製備方法。具體地，本發明涉及6‑乙酰基‑8‑環戊基‑5‑甲基‑2‑((5‑(哌啶‑4‑基)吡啶‑2‑基)氨基)吡啶并[2,3‑d]嘧啶‑7(8H)‑酮羥乙基磺酸鹽(式(I)化合物)，其I型結晶及其製備方法。本發明所得到式(I)化合物的I型結晶具備良好的化學穩定性和晶型穩定性，幷且所用結晶溶劑低毒低殘留，可更好地用於臨床治療。
